Greek coach Fernando Santos must find replacements for Avraam Papadopoulos, who is out of the tournament with a knee injury, and Sokratis Papastathopoulos who is suspended after being harshly dismissed against Poland in the Group A opener.
The pair anchored a defence that conceded only five goals in qualifying and Santos will likely pair veteran midfielder Costas Katsouranis with 20-year old Kyriakos Papadopoulos who came on for his namesake in the 1-1 draw against the co-hosts.
The Czechs have defensive issues as well but their problems are mostly of their own making after Russia ran riot in a 4-1 victory on Friday, mainly due to glaring mistakes at the back.
Czech coach Michal Bilek might be tempted to move Michal Kadlec back to central defence from the left side and bring in David Limbersky, while defensive midfielder Tomas Hubschman could also start the game to reinforce the rearguard.
Despite their terrible start to the tournament, Czech defender Roman Hubnik said the difficulty they had qualifying for the finals after a playoff with Montenegro will help them deal with the pressure against Greece in Wroclaw.